CYTOKINE NEWS: 2008

Alonzo Peters MD FAAFP*
* Fellow American Academy of Family Practice contact : pete4doc@hotmail.com 713-882-7209
AML –Acute Myelogenous Leukemia
(Cancer), Coagulation, and BiPolar Disorders,
as examples of immune dysfunction as well as
factors associated with natural anti-iflammatory function Part of Advanced Medical Informatic and Education’s
AMIE TM
justification
An argument and Medical Manifesto of all physiology/pathophysiology as relative to a proposed
Cytokine Physiologic AntiInflammatory Cascade which articulates with heretofore known Urea, Glycolytic, respiratory, TCA, glutathione chains/cycle as an aid to the citizens of the USA and world in disease prevention and treatment

BackGround 12-03-07

We classically looked at Inflammation as Dolor, Rubor, Calor and loss of function. Yet without knowing the actual function or physiology of the ‘flame” in inflammation we were at loss to know some of its dysfunction in inflammation. Cytokines, aka Interleukins –Ils(1), and their receptors including, IL10 (Interleukin 10) , IL6 , IL8, TNF (tumor necrosis factor)1, all appear to be involved in AML and cancer in general as well as many other processes which lead to disease (4). As yet Cytokines and their receptors have not been related to all normal physiologic processes including conception and all disease. Cytokines and their receptors have been related to a MODEL (see below) of an invented Pathophysiology of Inflammatory Manifestations and Process (IMPay) . This in essence originally related only a limited number of diseases to a pathophysiologic inflammatiory cascade as being responsible for the consequences of only a few diseases including AML,MS and Lupus..

On the other hand, a software that relates the IMPay MODEL with the known physology of the Neuro-Humeral-Immune ( NHI)(5) function was later named AMIE TM. ( a product of Peters’ Production and C and P Construction). This coordination of AMIE TM, NHI and heretofore established metabolic cycles including Krebs, Glycolytic, Respiratory, Glutathione Urea, endocrine along with newly discovered Human Genome Project (including micro RNA) allows for the lumping of all medical data into a query data-base for comparison and critique of potential exacerbating and curative variables. This is made possible only through computers and software. We have invented the software and propose a new MODEL which integrates the aforementioned to all DISease and normal physiology of the inflammatory process which sometimes does not result in inflammation.

Part of this integration acknowledges cytokine physiology, action and function as a type of hormone. A cytokine appears to be similar to the endocrine hormone’s (6) in 1. stimulating a receptor, 2. receptor-cytokine movement towards the nucleus and 3. subsequently stimulation of transcription and translation. Thus AMIE TM supercedes all previous medical knowledge in incorporating newly discovered principles measured in nanomoler quantities as cytokines (interchanchably referred to as interleukins IL-x) and their receptors into a paradigm of a hypothesized integrative chain. If f gone awry the MODEL results in dis-ease including psychiatric(7).

The motivation and courage for discovering the possibilities of cures from other sources included James Fredrick Jones death of leukemia, childhood buddies Leatha Mayes Cassandra Williams Edwin Temple’s deaths from Lupus / MS and last but not least the Leonard Moises death from renal cell carcinoma .

In summary AMIE TM is tripartite,3D and involves 1. A Physiologic Model of Inflammation involving the normal physiology of Inflammation proposing an end in Th1 and Th2 manifestations of normal physiologic and pathophysiologic nature 2. An Abbreviation Data Base 3. A Dialectic Query Centered Database assimilating and questioning the totality of pre-existing biochemical, chemical, physics, physiologic, mathematical, linguistic, eastern/African medical and Index Medicus data.

This in essence identifies contradictions and eliminates potential duplicated and erroneous data. It also shows the importance of a cision of the CiC - inflammatory cascade into a Th1 (predominantly cellular inflammatory nomenclature response (compare to catabolic) of IL1, IL6 and TNF division and a Th2 (IL4. IL10) division of maintenance and specificity via antibodies and allergy (compare to anabolic)
Original Cytokine Cascade of inflammation and its Consequence
IMPay MODEL+ available to expand

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Friday, February 22, 2008

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Have you ever heard of cytokines and normal body functions?